Tipranavir is one of a new class of HIV protease inhibitors called dihydropyrones  or non-peptidic protease inhibitors. It is designed to be active against HIV strains that have become resistant to other protease inhibitors. For this reason it is most useful in salvage or multiple-treatment experienced regimens.

Basic info

Generic name tipranavir
Brand name Aptivus
Also known as
Drug class Protease Inhibitors
Pediatric dosing? Available in doses suitable for children and/or young people.
Availability in Australia Available on the Pharmaceutical Benefits Scheme (PBS) through S100 prescribers since
This drug may be available through clinical trials in Australia.
You may be able to import this drug from overseas for your personal use.
Formulation 250mg capsule

Taking it

Like most anti-HIV drugs, tipranavir must be taken in combination with other drugs to be completely effective. Commonly, tipranavir is combined with one other nucleoside (NRTI) drug and either a protease inhibitor or non-nucleoside, although other combinations are sometimes used. Your doctor will advise you on the right combination of drugs to suit your circumstances.


2 x 250mg capsules + 200mg ritonavir twice daily

Regardless of what you read on this website or elsewhere, you should always take your medications according to your doctor's instructions. If you're unsure, speak to your doctor or pharmacist.

With or without food

tipranavir should be taken with food

Side effect

All drugs can produce side effects in some people. These may be mild, moderate or severe, so you should be aware of potential side effects before starting any drug, and speak to your doctor if you experience side effects that concern you.

  • Common side effects may include nausea (upset stomach, feeling sick to the stomach), diarrhoea, vomiting, headache, fatigue, stomach pain.
  • Less common side effects may include rash or sensitivity to the sun, joint pain or stiffness, itching, tightness in the throat..
  • Rare side effects may include hepatitis, increases in cholesterol and triglycerides (blood fats), liver failure.
  • It's unlikely you will experience all of these side effects, and you may not experience any side effects at all. Before starting any new drug, ask your doctor about side effects you might experience and discuss strategies for dealing with side effects if they do occur. If you experience any significant side effect you should continue taking your medicine and see your doctor as soon as possible.

Interactions with other drugs

Drugs to watch out for include other ARVs, drugs to treat tuberculosis, for erectile dysfunction (such as Viagra), for heart rhythm (antiarrhythmics), and for migraine headaches. Interactions are also possible with several antihistamines (allergy medications), sedatives, drugs to lower cholesterol, and anti-fungal drugs. Tipranavir raises blood levels of midazolam, a sedative. They should not be taken together without careful monitoring. Some birth control pills may not work if you are taking tipranavir. Tipranavir lowers blood levels of methadone. Watch for signs of excessive sedation if you take tipranavir with buprenorphine. The herb St. John's Wort lowers the blood levels of some protease inhibitors. Do not take it while taking tipranavir.