Maraviroc is a CCR5 blocker.  Maraviroc targets the CCR5 co-receptor used by HIV to gain entry to CD4 cells.  It works by attaching to a protein on the surface of CD4 cells called CCR5, blocking the virus from entering the cell.  Drugs in this class are called CCR5 antagonists, and may also be referred to as attachment inhibitors or entry inhibitors. 

Because CCR5 antagonists prevent HIV from entering immune system cells, they don't cause side effects associated with other HIV treatments that work against HIV inside the CD4 cells. 

HIV can use another protein to enter CD4 cells, CXCR4.  It is possible for someone to have CCR5 or CXCR4 surface proteins, or both CXCR4 and CCR5 types of HIV.

A blood test can tell your tropism, and Maraviroc should only be used for people who have only CCR5 tropic HIV.  It is estimated that over 90% of people newly diagnosed with HIV have exclusively CCR5 tropic HIV.

Basic info

Generic name maraviroc
Brand name Celsentri
Also known as MVC
Drug class Entry Inhibitors
Pediatric dosing? Available in doses suitable for children and/or young people.
Availability in Australia Available on the Pharmaceutical Benefits Scheme (PBS) through S100 prescribers since 2010
A restricted Special Assistance Scheme (SAS) is in operation for this drug.
This drug may be available through clinical trials in Australia.
You may be able to import this drug from overseas for your personal use.
Formulation 150mg tablets, and 300mg tablets.

Taking it

Like most anti-HIV drugs, maraviroc must be taken in combination with other drugs to be completely effective. Commonly, maraviroc is combined with one other nucleoside (NRTI) drug and either a protease inhibitor or non-nucleoside, although other combinations are sometimes used. Your doctor will advise you on the right combination of drugs to suit your circumstances.


The usual dose of Maraviroc is 150 mg, 300 mg or 600 mg twice a day.  The dosage prescribed will depend on other medications, including some HIV treatments that someone might also be taking that can effect the blood levels of Maraviroc.

Always take the dose recommended by your doctor, and tell your doctor(s) and pharmacist(s) about all medication and supplements that you are taking.

Do not take St John's Wort with any HIV treatments as it can reduce the levels of HIV treatments in your body, making them less effective and risking resistance.

Regardless of what you read on this website or elsewhere, you should always take your medications according to your doctor's instructions. If you're unsure, speak to your doctor or pharmacist.

With or without food

maraviroc may be taken with or without food

Side effect

All drugs can produce side effects in some people. These may be mild, moderate or severe, so you should be aware of potential side effects before starting any drug, and speak to your doctor if you experience side effects that concern you.

Interactions with other drugs

Some other drugs can affect the levels of maraviroc in your body, and always tell your doctor(s) and pharmacist(s) about all medications you are taking including supplements, over-the-counter medicines and herbal treatments.