lopinavir + ritonavir

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HIV seems to have a hard time developing resistance to Kaletra, it has even been shown to work well as a monotherapy. Great viral load results for people on their first HIV regimen. Good results also for those heavily treatment-experienced, even those with protease inhibitor resistance.

Once daily dosing can increase side effects, especially diarrhoea, and is not recommended for pregnant women or anyone under 18. People with liver damage should avoid Kaletra altogether.

Basic info

Generic name lopinavir + ritonavir
Brand name Kaletra
Also known as ABT-378
Drug class Protease Inhibitors
Pediatric dosing? Available in doses suitable for children and/or young people.
Availability in Australia Available on the Pharmaceutical Benefits Scheme (PBS) through S100 prescribers since
This drug may be available through clinical trials in Australia.
You may be able to import this drug from overseas for your personal use.
Formulation 200mg + 50mg ritonavir tablet; Oral solution

Taking it

Like most anti-HIV drugs, lopinavir + ritonavir must be taken in combination with other drugs to be completely effective. Commonly, lopinavir + ritonavir is combined with one other nucleoside (NRTI) drug and either a protease inhibitor or non-nucleoside, although other combinations are sometimes used. Your doctor will advise you on the right combination of drugs to suit your circumstances.


Take two 200mg/50mg tablets twice a day

Regardless of what you read on this website or elsewhere, you should always take your medications according to your doctor's instructions. If you're unsure, speak to your doctor or pharmacist.

With or without food

lopinavir + ritonavir may be taken with or without food

Side effect

All drugs can produce side effects in some people. These may be mild, moderate or severe, so you should be aware of potential side effects before starting any drug, and speak to your doctor if you experience side effects that concern you.

  • Common side effects may include nausea (upset stomach, feeling sick to the stomach), diarrhoea, headache, abdominal pain, feeling weak or tired.
  • Less common side effects may include lipodystrophy, lactic acidosis, rasied sugar or fat levels, joint pain or stiffness.
  • Rare side effects may include hyperlipidaemia, abnormal liver function.
  • It's unlikely you will experience all of these side effects, and you may not experience any side effects at all. Before starting any new drug, ask your doctor about side effects you might experience and discuss strategies for dealing with side effects if they do occur. If you experience any significant side effect you should continue taking your medicine and see your doctor as soon as possible.

Interactions with other drugs

Follow the link to PBS Consumer Medicine Information for a comprehensive list of drugs you should avoid while taking Kaletra.