dolutegravir + abacavir + 3TC

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TRIUMEQ is a single pill that combines three different HIV drugs. These are an integrase inhibitor called dolutegravir plus two NRTIs (nukes) called abacavir and3TC (lamivudine). TGA approved Triumeq on 14th January 2015

There is a caution for drug interactions with some supplements, antiacids and multivitamins. This requires separating the dolutegravir dose by at least four hours.

Before using Triumeq you need a blood test to check you are not likely to get a reaction to abacavir. If you test positive for a gene called HLA*B-5701 you should not use any combinations that include abacavir. This includes Kivexa and Triumeq.

An additional dose of dolutegravir is needed if Triumeq is used with the following drugs: efavirenz, fosamprenavir/ritonavir, tipranavir/ritonavir, or rifampin.

Side effects are generally mild and uncommon. For example. the most commonly reported side effects in studies were insomnia, headache and feeling tired (in 3%, 2% and 2% of people). These were similar to other HIV combinations. They were not reported by most people and they caused very few people to stop treatment. See information about the individual drugs in Triumeq for more information on side effects.

Triumeq is approved by PBS.

Basic info


Generic name dolutegravir + abacavir + 3TC
Brand name Triumeq
Also known as N/A
Drug class Fixed Dose Combinations
Pediatric dosing? Available in doses suitable for children and/or young people.
Availability in Australia Available on the Pharmaceutical Benefits Scheme (PBS) through S100 prescribers since 2015
You may be able to import this drug from overseas for your personal use.
Formulation Triumeq contains 50 mg of dolutegravir (as dolutegravir sodium), 600 mg of abacavir (as abacavir sulfate) and 300mg lamivudine as the active ingredients.
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Taking it

This product contains multiple medicines which comprise a complete antiretroviral regimen for most people. However your doctor may prescribe other antiretrovirals to be taken in combination with dolutegravir + abacavir + 3TC if needed. Your doctor will advise you on the right combination of drugs to suit your circumstances.


Dosage

Standard adult dose (age 12 and older): 1 pill once-daily.

Regardless of what you read on this website or elsewhere, you should always take your medications according to your doctor's instructions. If you're unsure, speak to your doctor or pharmacist.


With or without food

dolutegravir + abacavir + 3TC may be taken with or without food

Side effect

All drugs can produce side effects in some people. These may be mild, moderate or severe, so you should be aware of potential side effects before starting any drug, and speak to your doctor if you experience side effects that concern you.


  • Common side effects may include Nil.
  • Less common side effects may include insomnia, headache and feeling tired (in 3%, 2% and 2% of people).
  • It's unlikely you will experience all of these side effects, and you may not experience any side effects at all. Before starting any new drug, ask your doctor about side effects you might experience and discuss strategies for dealing with side effects if they do occur. If you experience any significant side effect you should continue taking your medicine and see your doctor as soon as possible.

Interactions with other drugs

There is a caution for drug interactions with some supplements, antacids and multivitamins. This requires separating the dolutegravir dose by at least four hours.