Darunavir is a PI which was specifically developed to control HIV that is already resistant to some other protease inhibitors, so was first used for more treatment-experience people. It is now also one of the preferred PIs used in first-line regimens.

It is always prescribed to be taken with a low-dose of ritonavir.

Basic info

Generic name darunavir
Brand name Prezista
Also known as TMC114
Drug class Protease Inhibitors
Pediatric dosing? Available in doses suitable for children and/or young people.
Availability in Australia Available on the Pharmaceutical Benefits Scheme (PBS) through S100 prescribers since
This drug may be available through clinical trials in Australia.
You may be able to import this drug from overseas for your personal use.
Formulation 800mg tablet; 600mg tablet

Taking it

Like most anti-HIV drugs, darunavir must be taken in combination with other drugs to be completely effective. Commonly, darunavir is combined with one other nucleoside (NRTI) drug and either a protease inhibitor or non-nucleoside, although other combinations are sometimes used. Your doctor will advise you on the right combination of drugs to suit your circumstances.


For treatment experienced people the normal dose is one 800mg tablet (plus 100mg of ritonavir) taken once a day with food.

Regardless of what you read on this website or elsewhere, you should always take your medications according to your doctor's instructions. If you're unsure, speak to your doctor or pharmacist.

With or without food

darunavir should be taken with food

Side effect

All drugs can produce side effects in some people. These may be mild, moderate or severe, so you should be aware of potential side effects before starting any drug, and speak to your doctor if you experience side effects that concern you.

  • Common side effects may include nausea (upset stomach, feeling sick to the stomach), diarrhoea, headache, common cold.
  • Less common side effects may include skin rash, increases in cholesterol and triglycerides (blood fats).
  • Rare side effects may include hepatitis.
  • It's unlikely you will experience all of these side effects, and you may not experience any side effects at all. Before starting any new drug, ask your doctor about side effects you might experience and discuss strategies for dealing with side effects if they do occur. If you experience any significant side effect you should continue taking your medicine and see your doctor as soon as possible.

Interactions with other drugs

Because of decreased serum levels, darunavir should not be given with either lopinavir/ritonavir (Kaletra) or saquinavir (Invirase). Darunavir with ritonavir can interact with other drugs or supplements that you are taking. These interactions can change the amount of each drug in your bloodstream and cause an under- or overdose. New interactions are being identified all the time. Drugs to watch out for include drugs to treat tuberculosis, for erectile dysfunction (such as Viagra), antidepressants, drugs for heart rhythm (antiarrhythmics), and for migraine headaches. Interactions are also possible with several antihistamines (allergy medications), sedatives, drugs to lower cholesterol, and anti-fungal drugs. Some birth control pills may not work if you are taking darunavir. Darunavir lowers blood levels of methadone. Watch for signs of excessive sedation if you take darunavir with buprenorphine. The herb St. John's Wort lowers the blood levels of some protease inhibitors. Do not take it while taking darunavir.