abacavir + lamivudine + zidovudine

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Trizivir is a triple NRTI combination tablet containing 150mg lamivudine (3TC), 300mg abacavir and 300mg zidovudine (AZT).

It is not recommended for initial therapy but is considered beneficial for treatment-experienced people because of improved adherence and short-term tolerance.

Trizivir is not recommended for use during pregnancy, and should only be used when the drug's benefits outweigh its risks. Abacavir can cause a severe hypersensitivity reaction.

Basic info


Generic name abacavir + lamivudine + zidovudine
Brand name Trizivir
Also known as AZT/3TC/abacavir
Drug class Nucleoside/Nucleotide Reverse Transcriptase Inhibitors
Pediatric dosing? Available in doses suitable for children and/or young people.
Availability in Australia Available on the Pharmaceutical Benefits Scheme (PBS) through S100 prescribers since
This drug may be available through clinical trials in Australia.
You may be able to import this drug from overseas for your personal use.
Formulation 300mg/150mg/300mg tablet
Links:


Taking it

Like most anti-HIV drugs, abacavir + lamivudine + zidovudine must be taken in combination with other drugs to be completely effective. Commonly, abacavir + lamivudine + zidovudine is combined with one other nucleoside (NRTI) drug and either a protease inhibitor or non-nucleoside, although other combinations are sometimes used. Your doctor will advise you on the right combination of drugs to suit your circumstances.


Dosage

The normal adult dose is one (300mg/300mg/150mg) tablet twice a day.

Regardless of what you read on this website or elsewhere, you should always take your medications according to your doctor's instructions. If you're unsure, speak to your doctor or pharmacist.


With or without food

abacavir + lamivudine + zidovudine may be taken with or without food

Side effect

All drugs can produce side effects in some people. These may be mild, moderate or severe, so you should be aware of potential side effects before starting any drug, and speak to your doctor if you experience side effects that concern you.


  • Common side effects may include nausea (upset stomach, feeling sick to the stomach), diarrhoea, vomiting, depression, dizziness, abdominal pain, constipation, muscle aches.
  • Less common side effects may include rash, blood disorders, muscle damage, neutropenia, hair loss.
  • Rare side effects may include serious hypersensitivity reaction which may be life-threatening, lactic acidosis with hepatic steatosis.
  • It's unlikely you will experience all of these side effects, and you may not experience any side effects at all. Before starting any new drug, ask your doctor about side effects you might experience and discuss strategies for dealing with side effects if they do occur. If you experience any significant side effect you should continue taking your medicine and see your doctor as soon as possible.

Interactions with other drugs

For more information follow the above link to The Body.