PEP guidelines (2nd edition)

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29 Sep 2016

These guidelines outline the management of individuals who have been exposed (or suspect they have been exposed) to HIV in non-occupational and occupational settings. There are currently no data from randomised controlled trials of the use of post-exposure prophylaxis (PEP) and evidence for use has been extrapolated from animal data, mother to child transmission, occupational exposure and small prospective studies of PEP regimens in HIV-negative men. Accordingly, assumptions are made about the direction of management.

Every presentation for PEP should be assessed on a case-by-case basis, balancing the potential harms and benefits of treatment.

This second edition of the National PEP guidelines is:

  • revised from the first National PEP guidelines released in 2013, which replaced the National guidelines for Non-Occupational Post-Exposure Prophylaxis to HIV (DoH 2006) and the HIV component of the Management of Exposure to Blood/Body Fluids in an Occupational Health Setting, ANCAHRD Bulletin No 29 September 2002
  • produced by the Australasian Society for HIV, Viral Hepatitis and Sexual Health Medicine (ASHM)
  • available as a website resource at www.pep.guidelines.org.au
  • also located at www.ashm.org.au/pep-guidelines
  • funded by the Commonwealth Department of Health (DoH)
  • to be reviewed regularly through ASHM , for advice to the DoH
  • supported by a Literature Review1 and other documents also available at the above websites.