Viral load

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Post by Jae14 Apr 2014

Viral load is the term used to describe the amount of HIV in your blood. The more HIV there is in your blood (and therefore the higher your viral load), then the faster your CD4 cell count will fall, and the greater your risk of becoming ill because of HIV.

Viral load tests measure the amount of HIV’s genetic material in a blood sample. The results of a viral load test are described as the number of copies of HIV RNA in a millilitre of blood. But your doctor will normally just talk about your viral load as a number. For example, a viral load of 10,000 would be considered low; 100,000 would be considered high. Viral load changes can be very large, so they are sometimes quantified using the powers of ten, or ‘log scale’. A 1-log change is the same as a ten-fold change (so 5,000 to 50,000 or vice versa); a 2-log change is a 100-fold change and is written as 102.

Your viral load if you are not taking HIV treatment

You should have your viral load measured when you are first diagnosed with HIV. If it is known that you have very recently become HIV positive (a period known as primary infection), you will have it measured three to six months later to determine your viral load ‘set point’ – the level of your viral load once it stabilises when the period of primary infection is over.

Your viral load will be monitored at your regular HIV clinic appointments – generally twice a year if you don’t have any symptoms. This is because the level of your viral load can provide important information about the way that HIV might affect your health if it is left untreated. Amongst people with the same CD4 cell count, those with a high viral load tend to lose CD4 cells and become ill faster.

When you’re not taking HIV treatment, the level of your viral load can fluctuate between tests. Often increases in your viral load are nothing to worry about. Even a doubling in your viral load might not be significant.

Vaccinations, such as a flu injection, and infections can cause a temporary increase in your viral load. Talk to your doctor about whether you should delay your next viral load test – sometimes it is recommended to wait at least one month after having a vaccination or getting over an infection.

Like your CD4 count, it’s best to look at the trend in your viral load over time. When viral load results over several months show a continuing increase, or when the increase is greater than three-fold, there may be a cause for concern.

For example, an increase from 5,000 to 15,000 shouldn’t cause you to worry when you are not on treatment. A rise from 50,000 to 100,000 may not be significant, but a rise from 5,000 to 25,000 is likely to be significant. This result suggests your viral load is five times the level it was at your last viral load test.

Your doctor will probably want to confirm this trend with a repeat test.

When you’re thinking about starting HIV treatment, one of the factors your doctor will discuss with you is your viral load. As mentioned earlier, it is recommended that people start HIV treatment when their CD4 cell count is around 350. Your viral load can also be a factor in choosing which anti-HIV drugs you start treatment with.

You’ll have a viral load test just before you start HIV treatment.

Viral load if you are taking HIV treatment

Your viral load should start to fall once you start HIV treatment. Taking your treatment in the right way, every day, gives it the best chance of working. If you’re having difficulty taking your treatment, for any reason, it is really important to talk to your doctor or another member of your healthcare team about it.

Your doctor will check your viral load within a month of starting treatment, and again three months after starting. Your viral load four weeks after starting HIV treatment is a good indicator of whether it will become undetectable on this combination of anti-HIV drugs.

The aim of HIV treatment is an undetectable viral load. Your viral load should have fallen to undetectable levels within three to six months of starting HIV treatment. If this doesn’t happen, your doctor will talk to you about possible reasons for this and next steps.

Once you have an undetectable viral load, you will have your viral load monitored every three to four months. If you have had an undetectable viral load for some time and are doing well on treatment, your doctor may offer you the option to have your viral load measured every six months.

Undetectable viral load

All viral load tests have a cut-off point below which they cannot reliably detect HIV. This is called the limit of detection. Tests used most commonly in the UK have a lower limit of detection of either 40 or 50 copies/ml, but there are some very sensitive tests that can measure below 20 copies/ml. If your viral load is below 50, it is usually said to be undetectable. The aim of HIV treatment is to reach an undetectable viral load.

But just because the level of HIV is too low to be measured doesn’t mean that HIV has disappeared completely from your body. It might still be present in the blood, but in amounts too low to be measured. Viral load tests only measure levels of HIV in the blood, which may be different to the viral load in other parts of your body, for example in your genital fluids, gut or lymph nodes.

Why it’s good to have an undetectable viral load

Having an undetectable viral load is important for a number of reasons.

First of all, because your immune system is able to recover and become stronger, it means that you have a very low risk of becoming ill because of HIV. It also reduces your risk of developing some other serious illnesses as well. There is some evidence that the presence of HIV (especially a higher viral load) can increase the risk of cardiovascular disease (illnesses such as heart disease and stroke).

Secondly, having an undetectable viral load means that the risk of HIV becoming resistant to the anti-HIV drugs you are taking is very small.

Finally, having an undetectable viral load reduces the risk of passing on HIV to someone else. This is discussed in more detail below.

Detectable viral load if you are taking HIV treatment

If your viral load hasn’t fallen to undetectable levels within three to six months of starting HIV treatment, then your doctor will talk to you about your current treatment. They may ask some detailed questions about how and when you take your anti-HIV drugs and whether you have taken any other drugs – including prescription, over-the-counter, herbal or recreational drugs ­­– at the same time. This is because not taking treatment regularly, or interactions with other drugs, can cause the levels of anti-HIV drugs in your body to be too low to work. You may have a blood test to look at the level of anti-HIV drugs in your blood and to see if your HIV has developed resistance to any drugs.

Then they will discuss the options with you. This may involve changing your anti-HIV drugs to find a combination that works for you.

Having a detectable viral load when you are taking HIV treatment can mean that your HIV will become resistant not only to the anti-HIV drugs you are taking, but also to other similar anti-HIV drugs as well.

If you are taking HIV treatment and have had an undetectable viral load, and then you have a test that shows a detectable viral load, you will need to have another test to confirm the result. It may just be what is called a viral load ‘blip’.

If later tests still show your viral load has become detectable again, you will probably need to change your HIV treatment. Your doctor will discuss your options with you.

Viral load blips

People with an undetectable viral load sometimes experience what are called ‘blips’ in their viral load. Their viral load increases from undetectable to a low but detectable level before becoming undetectable again on the next test.

Viral load blips do not necessarily show that your HIV treatment is no longer working.

There are a number of theories about the reasons for blips. These include variations in the laboratory processes, or having an infection like a cold or the flu.

If your viral load stays above detectable on two consecutive tests, or possibly if you have fairly frequent blips, your doctor will want to discuss possible causes and whether you need to change your treatment.

Viral load and sexual transmission of HIV

If you have a high viral load in your blood, then you might also have a high viral load in other body fluids, including your semen or vaginal fluid. People with high viral loads are more infectious and can pass HIV on more easily.

As well as reducing viral load in your blood, HIV treatment also reduces viral load in other body fluids, such as semen and vaginal fluid.

There’s been a lot of debate about how infectious someone is to their sexual partner if they are on HIV treatment and have an undetectable viral load.

It is clear that having an undetectable viral load when taking HIV treatment can greatly reduce the risk of HIV being passed on (sometimes called ‘treatment as prevention’). But, as yet, we don’t know whether having an undetectable viral load completely removes the risk of passing on HIV. Having an undetectable viral load in a blood test does not necessarily mean viral load would be undetectable in semen, vaginal fluids or breast milk. Viral load could fluctuate between tests and other factors can affect infectiousness. For example, sexually transmitted infections may cause virus levels to rise.

Looking at CD4 and viral load together

If you’re not currently taking HIV treatment, looking at your viral load and CD4 cell count can help predict your risk of becoming ill because of HIV in the future. While your CD4 cell count is the main indicator your doctor will use to help monitor the health of your immune system, viral load testing can also provide important information.

Among people with the same CD4 cell counts, research has shown that those with a higher viral load tend to develop symptoms more quickly than those with a lower viral load.

In addition, among people with the same viral load, those with lower CD4 cell counts tend to become ill more quickly.